{"id":3691,"date":"2026-07-21T06:30:03","date_gmt":"2026-07-21T06:30:03","guid":{"rendered":"https:\/\/www.hygieia.com.cn\/?page_id=3691"},"modified":"2026-07-30T02:39:30","modified_gmt":"2026-07-30T02:39:30","slug":"s-1-propenyl-l-cysteine-cn","status":"publish","type":"page","link":"https:\/\/www.hygieia.com.cn\/?page_id=3691","title":{"rendered":"S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178 (S1PC)"},"content":{"rendered":"<h2>\u4e00\u3001\u4ea7\u54c1\u6982\u8ff0<\/h2>\n<p>S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u662f\u4e00\u79cd\u542b\u786b\u6c28\u57fa\u9178\u884d\u751f\u7269\uff0c\u7531 L-\u534a\u80f1\u6c28\u9178\u9aa8\u67b6\u548c 1-\u4e19\u70ef\u57fa\u4fa7\u94fe\u7ec4\u6210\u3002\u5b83\u662f\u719f\u6210\u5927\u849c\u63d0\u53d6\u7269\u4e2d\u7684\u7279\u5f81\u6027\u542b\u786b\u6210\u5206\u4e4b\u4e00\uff0c\u4e0e\u7814\u7a76\u8f83\u4e3a\u6210\u719f\u7684 S-\u70ef\u4e19\u57fa-L-\u534a\u80f1\u6c28\u9178\uff08S-allyl-L-cysteine, SAC\uff09\u5c5e\u4e8e\u7ed3\u6784\u5f02\u6784\u4f53\u3002<\/p>\n<p>S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u53ef\u5b58\u5728\u987a\u5f0f\u548c\u53cd\u5f0f\u51e0\u4f55\u5f02\u6784\u4f53\u3002\u73b0\u6709\u836f\u7406\u3001\u4ee3\u8c22\u53ca\u5065\u5eb7\u8001\u9f84\u5316\u7814\u7a76\u4e3b\u8981\u56f4\u7ed5\u53cd\u5f0f S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u5f00\u5c55\u3002<\/p>\n<h3>1. \u4ea7\u54c1\u57fa\u672c\u4fe1\u606f<\/h3>\n<table style=\"width: 100%; border-collapse: collapse; margin-bottom: 20px;\">\n<thead>\n<tr style=\"background-color: #f2f2f2;\">\n<th style=\"border: 1px solid #ddd; padding: 8px; text-align: left; width: 30%;\">\u9879\u76ee<\/th>\n<th style=\"border: 1px solid #ddd; padding: 8px; text-align: left;\">\u4fe1\u606f<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>\u4e2d\u6587\u540d\u79f0<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>\u82f1\u6587\u540d\u79f0<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">S-1-Propenyl-L-cysteine<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>\u63a8\u8350\u89c4\u8303\u540d\u79f0<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">trans-S-(1-Propenyl)-L-cysteine<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>\u7814\u7a76\u7b80\u79f0<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">S1PC<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>CAS\u53f7<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">52438-09-2<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>\u5206\u5b50\u5f0f<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">C\u2086H\u2081\u2081NO\u2082S<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>\u76f8\u5bf9\u5206\u5b50\u8d28\u91cf<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">161.22 g\/mol<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>\u6210\u5206\u7c7b\u522b<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u6c34\u6eb6\u6027\u542b\u786b\u6c28\u57fa\u9178\u884d\u751f\u7269<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>\u4e3b\u8981\u7814\u7a76\u6765\u6e90<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u719f\u6210\u5927\u849c\u63d0\u53d6\u7269\u53ca\u8471\u5c5e\u690d\u7269\u542b\u786b\u4ee3\u8c22\u4f53\u7cfb<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>\u7acb\u4f53\u5316\u5b66<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">L-\u6784\u578b<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\"><strong>\u5316\u5b66\u7ed3\u6784\u7c7b\u522b<\/strong><\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u542b\u786b\u6c28\u57fa\u9178 (S-alkenyl cysteine\u7c7b)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>2. \u4ea7\u54c1\u5b9a\u4f4d<\/h3>\n<p>\u4e00\u79cd\u56f4\u7ed5<strong>\u8102\u80aa\u7ec4\u7ec7\u2014\u4e0b\u4e18\u8111\u2014\u9aa8\u9abc\u808c\u8de8\u5668\u5b98\u901a\u4fe1<\/strong>\u3001<strong>eNAMPT \u5206\u6ccc<\/strong>\u53ca<strong>\u5065\u5eb7\u8001\u9f84\u5316<\/strong>\u5f00\u5c55\u7814\u7a76\u7684\u65b0\u578b\u542b\u786b\u6c28\u57fa\u9178\u539f\u6599\uff1a<\/p>\n<ul>\n<li>\u524d\u6cbf\u5065\u5eb7\u8001\u9f84\u5316\u7814\u7a76\u539f\u6599<\/li>\n<li>\u808c\u8089\u529f\u80fd\u4e0e\u5e74\u9f84\u76f8\u5173\u865a\u5f31\u7814\u7a76\u539f\u6599<\/li>\n<li>eNAMPT \u548c NAD\u207a \u8de8\u5668\u5b98\u8c03\u8282\u7814\u7a76\u539f\u6599<\/li>\n<li>\u8fd0\u52a8\u8010\u529b\u4e0e\u8102\u80aa\u9178\u80fd\u91cf\u4ee3\u8c22\u7814\u7a76\u539f\u6599<\/li>\n<li>\u708e\u75c7\u53cd\u5e94\u4e0e\u514d\u75ab\u5e73\u8861\u7814\u7a76\u539f\u6599<\/li>\n<\/ul>\n<hr \/>\n<p><!-- \u4e8c\u3001\u4e3b\u8981\u529f\u6548\u4e0e\u79d1\u5b66\u7814\u7a76\u65b9\u5411 --><\/p>\n<h2>\u4e8c\u3001\u4e3b\u8981\u529f\u6548\u4e0e\u79d1\u5b66\u7814\u7a76\u65b9\u5411<\/h2>\n<h3>2.1 \u5065\u5eb7\u8001\u9f84\u5316\u4e0e\u808c\u8089\u529f\u80fd<\/h3>\n<p>2026 \u5e74\u53d1\u8868\u4e8e\u300aCell Metabolism\u300b\u7684\u7814\u7a76\u5bf9\u8001\u9f84\u5c0f\u9f20\u8fdb\u884c\u4e86\u957f\u671f\u5e72\u9884\u3002\u7814\u7a76\u663e\u793a\uff0c\u957f\u671f\u6444\u5165 S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u53ef\u6539\u5584\u8001\u9f84\u5c0f\u9f20\u7684\u90e8\u5206\u9aa8\u9abc\u808c\u529b\u91cf\u6307\u6807\u3001\u4f53\u6e29\u8c03\u8282\u548c\u7efc\u5408\u865a\u5f31\u6307\u6570\u3002<\/p>\n<p>\u673a\u5236\u963b\u65ad\u5b9e\u9a8c\u63d0\u793a\uff0c\u8fd9\u4e9b\u4f5c\u7528\u4e0e\u4ee5\u4e0b\u73af\u8282\u6709\u5173\uff1a<\/p>\n<ul>\n<li>\u767d\u8272\u8102\u80aa\u7ec4\u7ec7 LKB1\u2014SIRT1 \u6fc0\u6d3b<\/li>\n<li>\u8102\u80aa\u7ec4\u7ec7 eNAMPT \u91ca\u653e<\/li>\n<li>\u4e0b\u4e18\u8111 NAD\u207a \u76f8\u5173\u4fe1\u53f7<\/li>\n<li>\u4ea4\u611f\u795e\u7ecf\u7cfb\u7edf\u6d3b\u52a8<\/li>\n<li>\u9aa8\u9abc\u808c\u795e\u7ecf\u652f\u914d\u53ca\u529f\u80fd\u72b6\u6001<\/li>\n<\/ul>\n<p>\u8fd9\u8bf4\u660e\u5176\u4f5c\u7528\u5e76\u975e\u7b80\u5355\u7684\u5c40\u90e8\u201c\u523a\u6fc0\u808c\u8089\u201d\uff0c\u800c\u53ef\u80fd\u4f9d\u8d56\u8de8\u5668\u5b98\u4ee3\u8c22\u548c\u795e\u7ecf\u901a\u4fe1\u3002<\/p>\n<h3>2.2 \u8fd0\u52a8\u8010\u529b\u4e0e\u8102\u80aa\u9178\u4ee3\u8c22<\/h3>\n<p>2024\u5e74\u53d1\u8868\u4e8e\u300aThe Journal of Nutrition\u300b\u7684\u52a8\u7269\u7814\u7a76\u4e2d\uff0c\u96c4\u6027\u5c0f\u9f20\u8fde\u7eed\u4e24\u5468\u53e3\u670d 6.5 mg\/kg \u4f53\u91cd\/\u5929\u7684 S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\uff0c<\/p>\n<p>\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a<\/p>\n<ul>\n<li>\u5c0f\u9f20\u6e38\u6cf3\u81f3\u529b\u7aed\u65f6\u95f4\u5ef6\u957f<\/li>\n<li>\u5fc3\u808c\u548c\u9aa8\u9abc\u808c CPT-1 \u6d3b\u6027\u589e\u5f3a<\/li>\n<li>\u4e19\u4e8c\u9170\u8f85\u9176A \u6c34\u5e73\u4e0b\u964d<\/li>\n<li>\u4e59\u9170\u8f85\u9176A \u6c34\u5e73\u5347\u9ad8<\/li>\n<li>\u5fc3\u808c\u548c\u9aa8\u9abc\u808c ATP \u6c34\u5e73\u5347\u9ad8<\/li>\n<li>\u8102\u80aa\u9178\u4ee3\u8c22\u76f8\u5173\u8840\u6d46\u4ee3\u8c22\u7269\u53d1\u751f\u53d8\u5316<\/li>\n<\/ul>\n<p>\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\uff0c\u5176\u53ef\u80fd\u901a\u8fc7\u63d0\u9ad8\u5fc3\u808c\u548c\u9aa8\u9abc\u808c\u8102\u80aa\u9178\u5229\u7528\uff0c\u4e3a\u8010\u529b\u8fd0\u52a8\u8fc7\u7a0b\u63d0\u4f9b\u80fd\u91cf\u3002<\/p>\n<h3>2.3 \u708e\u75c7\u53cd\u5e94\u4e0e\u514d\u75ab\u8c03\u8282<\/h3>\n<p>2018 \u5e74\u300aScientific Reports\u300b\u7814\u7a76\u53d1\u73b0\uff0cS-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u80fd\u591f\u4fc3\u8fdb TLR \u4fe1\u53f7\u9002\u914d\u86cb\u767d MyD88 \u964d\u89e3\uff0c\u5e76\u964d\u4f4e\u90e8\u5206 TLR \u4fe1\u53f7\u4ecb\u5bfc\u7684 IL-6 \u4ea7\u751f\u3002<\/p>\n<h3>2.4 <strong><b>\u5de8\u566c\u7ec6\u80de\u514d\u75ab\u5e73\u8861<\/b><\/strong><\/h3>\n<p>2021\u5e74\u7684\u7814\u7a76\u663e\u793a\uff0cS-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u53ef\u589e\u5f3aIL-10\u8bf1\u5bfc\u7684M2c\u6837\u5de8\u566c\u7ec6\u80de\u6781\u5316\uff0c\u5e76\u5ef6\u957fIL-10\u53d7\u4f53\u548cSTAT3\u76f8\u5173\u4fe1\u53f7\u7684\u6fc0\u6d3b\u65f6\u95f4\u3002<\/p>\n<p>M2c\u6837\u5de8\u566c\u7ec6\u80de\u901a\u5e38\u4e0e\u708e\u75c7\u6d88\u9000\u3001\u7ec4\u7ec7\u4fee\u590d\u53ca\u514d\u75ab\u8c03\u8282\u6709\u5173\u3002<\/p>\n<h2><strong><b>2.5<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>\u80a0\u9053\u9ecf\u819c\u514d\u75ab<\/b><\/strong><\/h2>\n<p>\u7814\u7a76\u663e\u793a\uff0cS-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u53ef\u901a\u8fc7ERK1\/2\u4f9d\u8d56\u7684XBP1\u8868\u8fbe\uff0c\u4fc3\u8fdb\u6d3e\u5c14\u96c6\u5408\u6dcb\u5df4\u7ed3\u4e2d\u7684B\u7ec6\u80de\u5411IgA\u4ea7\u751f\u7ec6\u80de\u5206\u5316\uff0c\u5e76\u63d0\u9ad8\u52a8\u7269\u80a0\u9053IgA\u6c34\u5e73\u3002<\/p>\n<p>\u8fd9\u4e00\u7ed3\u679c\u63d0\u793a\u5176\u5177\u6709\u80a0\u9053\u9ecf\u819c\u514d\u75ab\u7814\u7a76\u6f5c\u529b\u3002<\/p>\n<h2><strong><b>2.6<\/b><\/strong><strong><b>\u8840\u7ba1\u5185\u76ae\u5c4f\u969c<\/b><\/strong><\/h2>\n<p>2021\u5e74\u7814\u7a76\u53d1\u73b0\uff0c\u5728TNF-\u03b1\u8bf1\u5bfc\u7684\u4eba\u8110\u9759\u8109\u5185\u76ae\u7ec6\u80de\u6a21\u578b\u4e2d\uff0cS-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u80fd\u591f\u51cf\u8f7b\u5185\u76ae\u7ec6\u80de\u9ad8\u901a\u900f\u6027\uff0c\u4fdd\u62a4\u7ec6\u80de\u95f4\u8fde\u63a5\u86cb\u767d\uff0c\u5e76\u8c03\u8282GEF-H1\/RhoA\/Rac\u4fe1\u53f7\u3002<\/p>\n<p>\u8be5\u7ed3\u679c\u63d0\u793a\u5176\u53ef\u80fd\u652f\u6301\u708e\u75c7\u73af\u5883\u4e0b\u7684\u8840\u7ba1\u5185\u76ae\u5c4f\u969c\u7a33\u5b9a\u3002<\/p>\n<h2><strong><b>2.7<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>\u8840\u538b\u4e0e\u5916\u5468\u5faa\u73af<\/b><\/strong><\/h2>\n<p>\u5728\u81ea\u53d1\u6027\u9ad8\u8840\u538b\u5927\u9f20\u6a21\u578b\u4e2d\uff0cS-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u8868\u73b0\u51fa\u8840\u538b\u548c\u5916\u5468\u5faa\u73af\u76f8\u5173\u4f5c\u7528\u3002<\/p>\n<p>\u5176\u4ed6\u52a8\u7269\u7814\u7a76\u8fd8\u63d0\u793a\uff0c\u5176\u53ef\u80fd\u901a\u8fc7AMPK\/eNOS\/NO\u901a\u8def\u7f13\u89e3\u4f4e\u6e29\u8bf1\u5bfc\u7684\u5916\u5468\u8840\u6d41\u4e0b\u964d\u3002<\/p>\n<p>\u4e0a\u8ff0\u7ed3\u679c\u8bf4\u660e\u5176\u5177\u6709\u5fc3\u8840\u7ba1\u548c\u5916\u5468\u5faa\u73af\u7814\u7a76\u6f5c\u529b<\/p>\n<hr \/>\n<p><!-- \u4e09\u3001\u6838\u5fc3\u4f5c\u7528\u673a\u5236 --><\/p>\n<h2>\u4e09\u3001\u6838\u5fc3\u4f5c\u7528\u673a\u5236<\/h2>\n<h2><strong><b>3<\/b><\/strong><strong><b>.1 <\/b><\/strong><strong><b>\u6fc0\u6d3b\u8102\u80aa\u7ec4\u7ec7LKB1\u2014SIRT1\u4fe1\u53f7\u901a\u8def<\/b><\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p>2026 \u5e74\u53d1\u8868\u4e8e\u300aCell Metabolism\u300b\u7684\u7814\u7a76\u663e\u793a\uff0cS-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u53ef\u4f5c\u7528\u4e8e\u767d\u8272\u8102\u80aa\u7ec4\u7ec7\uff0c\u4fc3\u8fdbLKB1\u4e0eSTRAD\u3001MO25\u5f62\u6210\u6d3b\u6027\u590d\u5408\u4f53\uff0c\u4ece\u800c\u589e\u5f3aLKB1\u76f8\u5173\u4fe1\u53f7\uff0c\u5e76\u6fc0\u6d3b\u4e0b\u6e38SIRT1\u901a\u8def\u3002<\/p>\n<p>LKB1\u548cSIRT1\u5747\u53c2\u4e0e\u7ec6\u80de\u80fd\u91cf\u611f\u5e94\u3001\u7ebf\u7c92\u4f53\u4ee3\u8c22\u548c\u8870\u8001\u76f8\u5173\u8c03\u63a7\u3002\u8be5\u7814\u7a76\u7684\u91cd\u8981\u4ef7\u503c\u5728\u4e8e\uff0c\u5b83\u5c06S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u7684\u4f5c\u7528\u8d77\u70b9\u5b9a\u4f4d\u4e8e\u767d\u8272\u8102\u80aa\u7ec4\u7ec7\uff0c\u800c\u4e0d\u662f\u7b80\u5355\u5730\u5c06\u5176\u89e3\u91ca\u4e3a\u76f4\u63a5\u4f5c\u7528\u4e8e\u9aa8\u9abc\u808c\u3002<\/p>\n<h2><strong><b>3<\/b><\/strong><strong><b>.2 <\/b><\/strong><strong><b>\u4fc3\u8fdb\u8102\u80aa\u7ec4\u7ec7\u91ca\u653eeNAMPT<\/b><\/strong><\/h2>\n<p>NAMPT\uff0c\u5373\u70df\u9170\u80fa\u78f7\u9178\u6838\u7cd6\u8f6c\u79fb\u9176\uff0c\u662fNAD\u207a\u8865\u6551\u5408\u6210\u901a\u8def\u4e2d\u7684\u5173\u952e\u9650\u901f\u9176\u4e4b\u4e00\u3002<\/p>\n<p>\u90e8\u5206NAMPT\u53ef\u901a\u8fc7\u7ec6\u80de\u5916\u56ca\u6ce1\u7b49\u5f62\u5f0f\u7531\u8102\u80aa\u7ec6\u80de\u91ca\u653e\u8fdb\u5165\u5faa\u73af\uff0c\u8fd9\u79cd\u7ec6\u80de\u5916\u5f62\u5f0f\u88ab\u79f0\u4e3aeNAMPT\u3002\u7814\u7a76\u53d1\u73b0\uff0cS-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u80fd\u591f\u901a\u8fc7\u8102\u80aa\u7ec4\u7ec7LKB1\u2014SIRT1\u4fe1\u53f7\u4fc3\u8fdbeNAMPT\u91ca\u653e<sup>[3]<\/sup>\u3002<\/p>\n<p>\u56e0\u6b64\uff0cS-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u5e76\u4e0d\u662fNMN\u6216NR\u4e00\u7c7bNAD\u207a\u5408\u6210\u524d\u4f53\uff0c\u800c\u662f\u53ef\u80fd\u901a\u8fc7\u8c03\u8282\u5185\u6e90\u6027eNAMPT\u5206\u6ccc\uff0c\u95f4\u63a5\u53c2\u4e0e\u7ec4\u7ec7\u95f4NAD\u207a\u4ee3\u8c22\u901a\u4fe1\u3002<\/p>\n<h2><strong><b>3.3 <\/b><\/strong><strong><b>\u6784\u5efa\u201c\u8102\u80aa\u2014\u8111\u2014\u808c\u8089\u201d\u8de8\u5668\u5b98\u4fe1\u53f7\u901a\u8def<\/b><\/strong><\/h2>\n<p>\u52a8\u7269\u7814\u7a76\u8868\u660e\uff0c\u8102\u80aa\u7ec4\u7ec7\u91ca\u653e\u7684eNAMPT\u53ef\u5f71\u54cd\u4e0b\u4e18\u8111\u76f8\u5173NAD\u207a\u4ee3\u8c22\u548c\u795e\u7ecf\u4fe1\u53f7\uff0c\u968f\u540e\u901a\u8fc7\u4ea4\u611f\u795e\u7ecf\u7cfb\u7edf\u5f71\u54cd\u9aa8\u9abc\u808c\u529f\u80fd\u3002<\/p>\n<hr \/>\n<p><!-- \u56db\u3001\u4ea7\u54c1\u5e94\u7528\u65b9\u5411 --><\/p>\n<h2>\u56db\u3001\u4ea7\u54c1\u5e94\u7528\u65b9\u5411<\/h2>\n<h3>4.1 \u5065\u5eb7\u8001\u9f84\u5316\u4ea7\u54c1<\/h3>\n<p>\u9002\u5408\u7528\u4e8e\u56f4\u7ed5\u4ee5\u4e0b\u65b9\u5411\u5f00\u53d1\u7684\u914d\u65b9\uff1a<\/p>\n<ul>\n<li>\u5e74\u9f84\u76f8\u5173\u6d3b\u529b\u652f\u6301<\/li>\n<li>\u4e2d\u8001\u5e74\u808c\u8089\u529f\u80fd<\/li>\n<li>\u884c\u52a8\u529b\u4e0e\u4f53\u80fd\u7ef4\u6301<\/li>\n<li>\u8de8\u5668\u5b98\u4ee3\u8c22\u8c03\u8282<\/li>\n<li>eNAMPT\u548cNAD\u207a\u76f8\u5173\u5065\u5eb7\u8001\u9f84\u5316\u3002<\/li>\n<\/ul>\n<p>\u63a8\u8350\u5242\u578b\uff1a<\/p>\n<ul>\n<li>\u80f6\u56ca<\/li>\n<li>\u7247\u5242<\/li>\n<li>\u56fa\u4f53\u996e\u6599<\/li>\n<li>\u7c89\u5242<\/li>\n<li>\u5065\u5eb7\u8001\u9f84\u5316\u590d\u5408\u914d\u65b9<\/li>\n<\/ul>\n<h3>4.2 \u808c\u8089\u5065\u5eb7\u4ea7\u54c1<\/h3>\n<p>S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u53ef\u4e0e\u4f20\u7edf\u808c\u8089\u8425\u517b\u539f\u6599\u5f62\u6210\u5dee\u5f02\u5316\u3002<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin-bottom: 20px;\">\n<thead>\n<tr style=\"background-color: #f2f2f2;\">\n<th style=\"border: 1px solid #ddd; padding: 8px; text-align: left; width: 35%;\">\u539f\u6599\u7c7b\u578b<\/th>\n<th style=\"border: 1px solid #ddd; padding: 8px; text-align: left;\">\u4e3b\u8981\u4ea7\u54c1\u903b\u8f91<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u86cb\u767d\u8d28\u3001\u5fc5\u9700\u6c28\u57fa\u9178<\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u63d0\u4f9b\u808c\u8089\u86cb\u767d\u5408\u6210\u5e95\u7269<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u4eae\u6c28\u9178\u3001HMB<\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u8c03\u8282\u808c\u8089\u86cb\u767d\u5408\u6210\u548c\u5206\u89e3<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u7ef4\u751f\u7d20 D<\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u652f\u6301\u808c\u8089\u548c\u9aa8\u9abc\u5065\u5eb7<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u808c\u9178<\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u652f\u6301\u78f7\u9178\u539f\u4f9b\u80fd\u548c\u529b\u91cf\u8868\u73b0<\/td>\n<\/tr>\n<tr style=\"background-color: #f9f9f9;\">\n<td style=\"border: 1px solid #ddd; padding: 8px;\">S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178<\/td>\n<td style=\"border: 1px solid #ddd; padding: 8px;\">\u8102\u80aa\u2014\u8111\u2014\u808c\u8089\u4fe1\u53f7\u53ca\u5e74\u9f84\u76f8\u5173\u808c\u8089\u529f\u80fd\u7814\u7a76<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>4.3 <strong><b>\u8fd0\u52a8\u4e0e\u80fd\u91cf\u4ee3\u8c22\u4ea7\u54c1<\/b><\/strong><\/h3>\n<p>\u57fa\u4e8e\u52a8\u7269\u8102\u80aa\u9178\u4ee3\u8c22\u3001CPT-1\u3001ATP\u548c\u8010\u529b\u7814\u7a76\uff0c\u53ef\u7528\u4e8e\uff1a<\/p>\n<ul>\n<li>\u4e2d\u8001\u5e74\u8fd0\u52a8\u8425\u517b<\/li>\n<li>\u65e5\u5e38\u4f53\u80fd\u548c\u6d3b\u529b\u4ea7\u54c1<\/li>\n<li>\u8010\u529b\u578b\u8fd0\u52a8\u8425\u517b<\/li>\n<li>\u7ebf\u7c92\u4f53\u548c\u8102\u80aa\u9178\u5229\u7528\u76f8\u5173\u914d\u65b9<\/li>\n<\/ul>\n<p>\u7531\u4e8e\u4eba\u4f53\u8fd0\u52a8\u8868\u73b0\u8bc1\u636e\u5c1a\u4e0d\u5145\u5206\uff0c\u5efa\u8bae\u4f7f\u7528\u201c\u8fd0\u52a8\u80fd\u91cf\u4ee3\u8c22\u7814\u7a76\u201d\u201c\u8010\u529b\u652f\u6301\u6f5c\u529b\u201d\u7b49\u8868\u8fbe\u3002<\/p>\n<h2><strong><b>4<\/b><\/strong><strong><b>.4 <\/b><\/strong><strong><b>NAD\u207a \u7efc\u5408\u914d\u65b9<\/b><\/strong><\/h2>\n<p>\u53ef\u63a2\u7d22\u4e0e\u4ee5\u4e0b\u6210\u5206\u590d\u914d\uff1a<\/p>\n<ul>\n<li>NMN<\/li>\n<li>NR<\/li>\n<li>PQQ<\/li>\n<li>Ca-AKG<\/li>\n<li>\u8f85\u9176Q10<\/li>\n<li>\u9ea6\u89d2\u786b\u56e0<\/li>\n<li>\u4e9a\u7cbe\u80fa<\/li>\n<li>\u767d\u85dc\u82a6\u9187<\/li>\n<\/ul>\n<p>\u590d\u914d\u65f6\u5e94\u5206\u522b\u8bf4\u660e\u5404\u6210\u5206\u7684\u7814\u7a76\u901a\u8def\uff0c\u4e0d\u5b9c\u5c06\u591a\u79cd\u6210\u5206\u7b80\u5355\u53e0\u52a0\u5e76\u6982\u62ec\u4e3a\u201c\u534f\u540c\u6297\u8870\u201d\u3002<\/p>\n<hr \/>\n<p><!-- \u4e94\u3001\u4ea7\u54c1\u6838\u5fc3\u4f18\u52bf\u603b\u7ed3 --><\/p>\n<h2>\u4e94\u3001\u4ea7\u54c1\u6838\u5fc3\u4f18\u52bf\u603b\u7ed3<\/h2>\n<h3><strong><b>5.1 <\/b><\/strong><strong><b>\u673a\u5236\u5177\u6709\u5dee\u5f02\u5316<\/b><\/strong><\/h3>\n<p>S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u4e0d\u662f\u4f20\u7edfNAD\u207a \u524d\u4f53\uff0c\u5176\u6838\u5fc3\u7814\u7a76\u96c6\u4e2d\u4e8e\u8102\u80aa\u7ec4\u7ec7LKB1\u2014SIRT1 \u4fe1\u53f7\u3001eNAMPT \u5206\u6ccc\u4ee5\u53ca\u8102\u80aa\u2014\u8111\u2014\u808c\u8089\u8de8\u5668\u5b98\u901a\u4fe1\u3002<\/p>\n<h3><strong><b>5.2<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>\u7814\u7a76\u65b9\u5411\u5951\u5408\u5065\u5eb7\u8001\u9f84\u5316\u8d8b\u52bf<\/b><\/strong><\/h3>\n<p>\u5176\u7814\u7a76\u540c\u65f6\u6d89\u53ca\uff1a<\/p>\n<ul>\n<li>\u5e74\u9f84\u76f8\u5173\u808c\u8089\u529f\u80fd<\/li>\n<li>\u865a\u5f31\u72b6\u6001<\/li>\n<li>eNAMPT<\/li>\n<li>NAD\u207a\u4ee3\u8c22\u7f51\u7edc<\/li>\n<li>\u8102\u80aa\u7ec4\u7ec7\u5185\u5206\u6ccc\u529f\u80fd<\/li>\n<li>\u4e0b\u4e18\u8111\u548c\u4ea4\u611f\u795e\u7ecf<\/li>\n<li>\u8fd0\u52a8\u80fd\u91cf\u4ee3\u8c22<\/li>\n<\/ul>\n<h3><strong><b>5.3 <\/b><\/strong><strong><b>\u5df2\u5177\u5907\u521d\u6b65\u4eba\u4f53\u8f6c\u5316\u4f9d\u636e<\/b><\/strong><\/h3>\n<p>\u73b0\u6709\u7814\u7a76\u5df2\u4ece\u7ec6\u80de\u548c\u52a8\u7269\u673a\u5236\u63a8\u8fdb\u5230\u5355\u6b21\u4eba\u4f53eNAMPT\u751f\u7269\u6807\u5fd7\u7269\u8bd5\u9a8c\uff0c\u4f46\u5c1a\u9700\u957f\u671f\u4eba\u4f53\u529f\u6548\u548c\u5b89\u5168\u6027\u7814\u7a76\u3002<\/p>\n<h3><strong><b>5<\/b><\/strong><strong><b>.<\/b><\/strong><strong><b>4 <\/b><\/strong><strong><b>\u53ef\u5f62\u6210\u5dee\u5f02\u5316\u914d\u65b9\u903b\u8f91<\/b><\/strong><\/h3>\n<p>\u53ef\u4e0eNMN\u3001NR\u3001PQQ\u3001Ca-AKG\u3001\u8f85\u9176Q10\u548c\u4f20\u7edf\u808c\u8089\u8425\u517b\u539f\u6599\u5f62\u6210\u4e0d\u540c\u673a\u5236\u5c42\u9762\u7684\u7ec4\u5408\u3002<\/p>\n<h3><strong><b>5.5 <\/b><\/strong><strong><b>\u8bc1\u636e\u8fb9\u754c\u6e05\u6670<\/b><\/strong><\/h3>\n<p>\u76ee\u524d\u6700\u5f3a\u7684\u4eba\u4f53\u8bc1\u636e\u4e3a\u5355\u6b21\u6444\u5165\u540e\u7684\u5faa\u73afeNAMPT\u53d8\u5316\uff1b\u808c\u8089\u529b\u91cf\u3001\u865a\u5f31\u6307\u6570\u548c\u8010\u529b\u6539\u5584\u4ecd\u4e3b\u8981\u57fa\u4e8e\u52a8\u7269\u7814\u7a76\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u76f8\u5173\u539f\u6599\uff0c\u8bf7\u67e5\u770b\u6211\u4eec\u7684 <strong><a href=\"https:\/\/www.hygieia.com.cn\/?page_id=1078\">\u4ea7\u54c1\u4e2d\u5fc3<\/a><\/strong> \u6216<strong><a href=\"https:\/\/www.hygieia.com.cn\/\"> \u5173\u4e8e\u6211\u4eec<\/a><\/strong>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001\u4ea7\u54c1\u6982\u8ff0 S-1-\u4e19\u70ef\u57fa-L-\u534a\u80f1\u6c28\u9178\u662f\u4e00\u79cd\u542b\u786b\u6c28\u57fa\u9178\u884d\u751f\u7269\uff0c\u7531 L-\u534a\u80f1\u6c28\u9178\u9aa8\u67b6\u548c 1-\u4e19\u70ef\u57fa\u4fa7\u94fe\u7ec4\u6210\u3002 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":3693,"parent":3523,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-3691","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.hygieia.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/3691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hygieia.com.cn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.hygieia.com.cn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.hygieia.com.cn\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hygieia.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3691"}],"version-history":[{"count":6,"href":"https:\/\/www.hygieia.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/3691\/revisions"}],"predecessor-version":[{"id":3701,"href":"https:\/\/www.hygieia.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/3691\/revisions\/3701"}],"up":[{"embeddable":true,"href":"https:\/\/www.hygieia.com.cn\/index.php?rest_route=\/wp\/v2\/pages\/3523"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hygieia.com.cn\/index.php?rest_route=\/wp\/v2\/media\/3693"}],"wp:attachment":[{"href":"https:\/\/www.hygieia.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}